Peptides for Nerve Pain: Ziconotide, ARA-290 and BPC-157
Peptides for nerve pain, graded by evidence: ziconotide is FDA-approved for severe pain via spinal pump, ARA-290 had small trials, and BPC-157 is animal-only.
Pain & Nerve Peptides
Peptides studied for pain and nerve damage, from ARA-290 to the opioid peptide dermorphin: the evidence, the risks and the regulators’ view.
Peptide profiles
- Investigational
ARA-290 (Cibinetide)
Cibinetide · ARA 290 · ARA290
Innate repair receptor agonist (erythropoietin-derived peptide)
An 11-amino-acid peptide based on erythropoietin, tested in small phase 2 trials for nerve pain in sarcoidosis and type 2 diabetes. Not approved anywhere.
Read more - Not FDA-approved
Dermorphin
Frog juice · D-Peptide · H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
Mu-opioid receptor agonist (heptapeptide containing a D-amino acid)
A mu-opioid peptide from South American frog skin, far stronger than morphine in animal tests. Never approved, it is best known for 2012 racehorse doping cases.
Read more
Guides and research
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